Euhydric hypercapnia increases vasoreactivity of rat pulmonary arteries via HCO transport and depolarisation
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چکیده
منابع مشابه
Response of small pulmonary arteries to unilobar hypoxia and hypercapnia.
We measured the internal diameters of small muscular pulmonary arteries in the right and left lower lobes of lungs rapidly frozen in the anesthetized, open-thorax cat. In every cat the right lower lobe was ventilated with the test gas and all other lobes were ventilated with O2. In 4 cats, the test gas supplied to the right lower lobe was also O2 (control experiments); in 6, it was 100% N2 and ...
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Prolonged hypoxia causes pulmonary hypertension but no change in systemic vasomotor tone. In an effort to define the mechanisms involved, we determined the effects of 3 and 7 days of hypoxia on adenylate cyclase activity and fi-adrenergic receptor binding characteristics in pulmonary and systemic arteries in an adult rat model of hypoxic pulmonary vasoconstriction produced by hypobaria. Basal a...
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Objective(s): Drug-induced atrial fibrillation (AF) is considered an adverse effect of chemotherapeutic drugs. AF is a crucial risk factor for stroke, heart failure, myocardial infarction, and mortality. Pulmonary veins (PVs) are considered triggers inducing AF, and the sinoatrial node (SAN) may modulate PV activity and participate in AF genesis. AF was associated with...
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Past studies have demonstrated that 17beta-estradiol (E(2)beta) increases endothelial nitric oxide (NO) synthase (eNOS) activity in uterine, heart, and skeletal muscle and in cultured human endothelial cells. However, little is known about E(2)beta regulation of NO synthesis in the pulmonary vasculature. The present study evaluated E(2)beta regulation of eNOS function in pulmonary arteries and ...
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Gonzales, Rayna J., Benjimen R. Walker, and Nancy L. Kanagy. 17b-Estradiol increases nitric oxide-dependent dilation in rat pulmonary arteries and thoracic aorta. Am J Physiol Lung Cell Mol Physiol 280: L555–L564, 2001.—Past studies have demonstrated that 17b-estradiol (E2b) increases endothelial nitric oxide (NO) synthase (eNOS) activity in uterine, heart, and skeletal muscle and in cultured h...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2005
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2004.10.038